Davunetide for Progressive Supranuclear Palsy: a multicenter, randomized, double-blind, placebo controlled trial

BACKGROUND: Davunetide (AL-108, NAP) is an eightamino acid peptide that promotes microtubule stability and decreases tau phosphorylation in pre-clinical studies. Since PSP is tightly linked to tau pathology, davunetide could be an effective treatment for PSP.The goals of this study were to evaluate...

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Main Authors: Boxer, Adam L., Lang, Anthony E., Grossman, Murray, Knopman, David S., Miller, Bruce L., Schneider, Lon S., Doody, Rachelle S., Lees, Andrew, Golbe, Lawrence I., Williams, David R., Corvol, Jean-Cristophe, Ludolph, Albert, Burn, David, Lorenzl, Stefan, Litvan, Irene, Roberson, Erik D., Höglinger, Günter U., Koestler, Mary, Jack, Clifford R., Van Deerlin, Viviana, Randolph, Christopher, Lobach, Iryna V., Heuer, Hilary W., Gozes, Illana, Parker, Lesley, Whitaker, Steve, Hirman, Joe, Stewart, Alistair J., Gold, Michael, Morimoto, Bruce H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4129545/
https://ncbi.nlm.nih.gov/pubmed/24873720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1474-4422(14)70088-2
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