Identification and Validation of Genetic Variants that Influence Transcription Factor and Cell Signaling Protein Levels

Many genetic variants associated with human disease have been found to be associated with alterations in mRNA expression. Although it is commonly assumed that mRNA expression changes will lead to consequent changes in protein levels, methodological challenges have limited our ability to test the deg...

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Autors principals: Hause, Ronald J., Stark, Amy L., Antao, Nirav N., Gorsic, Lidija K., Chung, Sophie H., Brown, Christopher D., Wong, Shan S., Gill, Daniel F., Myers, Jamie L., To, Lida Anita, White, Kevin P., Dolan, M. Eileen, Jones, Richard Baker
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4129400/
https://ncbi.nlm.nih.gov/pubmed/25087611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2014.07.005
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