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INHIBITING GERANYLGERANYLATION INCREASES NEURITE BRANCHING AND DIFFERENTIALLY ACTIVATES COFILIN IN CELL BODIES AND GROWTH CONES
Inhibitors of the mevalonate pathway, including the highly prescribed statins, reduce the production of cholesterol and isoprenoids such as geranylgeranyl pyrophosphates. The Rho family of small guanine triphosphatases (GTPases) requires isoprenylation, specifically geranylgeranylation, for activati...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4128908/ https://ncbi.nlm.nih.gov/pubmed/24515839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-014-8653-5 |
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