INHIBITING GERANYLGERANYLATION INCREASES NEURITE BRANCHING AND DIFFERENTIALLY ACTIVATES COFILIN IN CELL BODIES AND GROWTH CONES

Inhibitors of the mevalonate pathway, including the highly prescribed statins, reduce the production of cholesterol and isoprenoids such as geranylgeranyl pyrophosphates. The Rho family of small guanine triphosphatases (GTPases) requires isoprenylation, specifically geranylgeranylation, for activati...

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Autors principals: Samuel, Filsy, Reddy, Jairus, Kaimal, Radhika, Segovia, Vianey, Mo, Huanbiao, Hynds, DiAnna L.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128908/
https://ncbi.nlm.nih.gov/pubmed/24515839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-014-8653-5
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