Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice

Rhadbomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and is subdivided in the embryonal (ERMS) and alveolar (ARMS) subtypes, the latter being associated with the worst prognosis. We report that sulforaphane (SFN), a broccoli-derived anticancer isothiocyanate, causes dose- and ti...

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Detalhes bibliográficos
Main Authors: Bergantin, Elisa, Quarta, Carmelo, Nanni, Cristina, Fanti, Stefano, Pession, Andrea, Cantelli-Forti, Giorgio, Tonelli, Roberto, Hrelia, Patrizia
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128864/
https://ncbi.nlm.nih.gov/pubmed/24971463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29684
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