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The mTOR kinase inhibitors polarize glioma-activated microglia to express a M1 phenotype
BACKGROUND: Increased activation of mammalian target of rapamycin (mTOR) is observed in numerous human cancers. Recent studies on the glioma kinome have identified several deregulated pathways that converge and activate mTOR. The available evidence on the role of microglia in CNS cancers would sugge...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4128534/ https://ncbi.nlm.nih.gov/pubmed/25051975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-11-125 |
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