Inactivation of thyA in Staphylococcus aureus Attenuates Virulence and Has a Strong Impact on Metabolism and Virulence Gene Expression

Staphylococcus aureus thymidine-dependent small-colony variants (TD-SCVs) are frequently isolated from patients with chronic S. aureus infections after long-term treatment with trimethoprim-sulfamethoxazole (TMP-SMX). While it has been shown that TD-SCVs were associated with mutations in thymidylate...

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Detalhes bibliográficos
Main Authors: Kriegeskorte, Andre, Block, Desiree, Drescher, Mike, Windmüller, Nadine, Mellmann, Alexander, Baum, Cathrin, Neumann, Claudia, Lorè, Nicola Ivan, Bragonzi, Alessandra, Liebau, Eva, Hertel, Patrick, Seggewiss, Jochen, Becker, Karsten, Proctor, Richard A., Peters, Georg, Kahl, Barbara C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128360/
https://ncbi.nlm.nih.gov/pubmed/25073642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01447-14
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