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Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo
In mammals, a cell’s decision to divide is thought to be under the control of the Rb/E2F pathway. We previously found that inactivation of the Rb family of cell cycle inhibitors (Rb, p107, and p130) in quiescent liver progenitors leads to uncontrolled division and cancer initiation. Here we show tha...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4128252/ https://ncbi.nlm.nih.gov/pubmed/25017070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.025 |
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