Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors

In the activated B-cell–like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL), NF-κB activity is essential for viability of the malignant cells and is sustained by constitutive activity of IκB kinase (IKK) in the cytoplasm. Here, we report an unexpected role for the bromodomain and extratermin...

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Hlavní autoři: Ceribelli, Michele, Kelly, Priscilla N., Shaffer, Arthur L., Wright, George W., Xiao, Wenming, Yang, Yibin, Mathews Griner, Lesley A., Guha, Rajarshi, Shinn, Paul, Keller, Jonathan M., Liu, Dongbo, Patel, Paresma R., Ferrer, Marc, Joshi, Shivangi, Nerle, Sujata, Sandy, Peter, Normant, Emmanuel, Thomas, Craig J., Staudt, Louis M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128109/
https://ncbi.nlm.nih.gov/pubmed/25049379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411701111
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