Molecular design of the N-methyl-D-aspartate receptor binding site for phencyclidine and dizolcipine.
The N-methyl-D-aspartate receptor (NMDAR), a pivotal entity for synaptic plasticity and excitotoxicity in the brain, is a target of psychotomimetic drugs such as phencyclidine (PCP) and dizolcipine (MK-801). In contrast, a related glutamate receptor, the alpha-amino-3-hydroxy-5-methyl-4-isoxazole pr...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41278/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7644531/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.17.8021 |
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