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Molecular design of the N-methyl-D-aspartate receptor binding site for phencyclidine and dizolcipine.

The N-methyl-D-aspartate receptor (NMDAR), a pivotal entity for synaptic plasticity and excitotoxicity in the brain, is a target of psychotomimetic drugs such as phencyclidine (PCP) and dizolcipine (MK-801). In contrast, a related glutamate receptor, the alpha-amino-3-hydroxy-5-methyl-4-isoxazole pr...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Ferrer-Montiel, A V, Sun, W, Montal, M
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41278/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7644531/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.17.8021
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