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Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D(3) in primary immune cells

Production of the human cathelicidin antimicrobial peptide gene (hCAP18/LL-37), is regulated by 1α,25-dihydroxyvitamin D(3) (1,25D3) and is critical in the killing of pathogens by innate immune cells. In addition, secreted LL-37 binds extracellular receptors and modulates the recruitment and activit...

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Detalhes bibliográficos
Main Authors: Lowry, Malcolm B., Guo, Chunxiao, Borregaard, Niels, Gombart, Adrian F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127358/
https://ncbi.nlm.nih.gov/pubmed/24565560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2014.02.004
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