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In vivo enrichment of genetically manipulated platelets corrects the murine hemophilic phenotype and induces immune tolerance even using a low MOI
BACKGROUND: Our previous studies have demonstrated that platelet-specific gene delivery to hematopoietic stem cells can induce sustained therapeutic levels of platelet-FVIII expression in hemophilia A (HA) mice. OBJECTIVE: In this study, we aimed to enhance platelet-FVIII expression while minimizing...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4127102/ https://ncbi.nlm.nih.gov/pubmed/24931217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12633 |
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