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New molecular engineering approaches for crystallographic studies of large RNAs

Crystallization of RNAs with complex three-dimensional architectures remains a formidable experimental challenge. We review a number of successful heuristics involving engineering of the target RNAs to facilitate crystal contact formation, such as those that enabled the crystallization and structure...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Jinwei, Ferré-D’Amaré, Adrian R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127099/
https://ncbi.nlm.nih.gov/pubmed/24607443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2014.02.001
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