In Vitro and In Vivo Evaluation of a Hydrogel Reservoir as a Continuous Drug Delivery System for Inner Ear Treatment

Fibrous tissue growth and loss of residual hearing after cochlear implantation can be reduced by application of the glucocorticoid dexamethasone-21-phosphate-disodium-salt (DEX). To date, sustained delivery of this agent to the cochlea using a number of pharmaceutical technologies has not been entir...

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Autors principals: Hütten, Mareike, Dhanasingh, Anandhan, Hessler, Roland, Stöver, Timo, Esser, Karl-Heinz, Möller, Martin, Lenarz, Thomas, Jolly, Claude, Groll, Jürgen, Scheper, Verena
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126769/
https://ncbi.nlm.nih.gov/pubmed/25105670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104564
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