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Frizzled fissure to improve central nervous system drug delivery?
Delivery of therapeutics to the brain is challenging because of efflux pumps located in the vascular endothelium. A detailed analysis of Wnt signaling in a human brain endothelial cell line indicates that expression and function of P-glycoprotein, a major efflux transporter, is controlled by non-can...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4126104/ https://ncbi.nlm.nih.gov/pubmed/24896568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.98 |
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