The cross-talk between canonical and non-canonical Wnt-dependent pathways regulates P-glycoprotein expression in human blood–brain barrier cells

In this work, we investigate if and how transducers of the ‘canonical' Wnt pathway, i.e., Wnt/glycogen synthase kinase 3 (GSK3)/β-catenin, and transducers of the ‘non-canonical' Wnt pathway, i.e., Wnt/RhoA/RhoA kinase (RhoAK), cooperate to control the expression of P-glycoprotein (Pgp) in...

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Detalhes bibliográficos
Main Authors: Pinzón-Daza, Martha L, Salaroglio, Iris C, Kopecka, Joanna, Garzòn, Ruth, Couraud, Pierre-Olivier, Ghigo, Dario, Riganti, Chiara
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Feature Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126086/
https://ncbi.nlm.nih.gov/pubmed/24896565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.100
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