Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl(4)-induced hepatic fibrosis

AIM: To investigate the anti-fibrosis effects of ginsenoside Rg1 on alcohol- and CCl(4)-induced hepatic fibrosis in rats and to explore the mechanisms of the effects. METHODS: Rats were given 6% alcohol in water and injected with CCl(4) (2 mL/kg, sc) twice a week for 8 weeks. Rg1 (10, 20 and 40 mg/k...

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Autori principali: Li, Jian-ping, Gao, Yan, Chu, Shi-feng, Zhang, Zhao, Xia, Cong-yuan, Mou, Zheng, Song, Xiu-yun, He, Wen-bin, Guo, Xiao-feng, Chen, Nai-hong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125711/
https://ncbi.nlm.nih.gov/pubmed/24976156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.41
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