Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting

AIM: To study if T-cell activation related to portasystemic shunting causes osteoclast-mediated bone loss through RANKL-dependent pathways. We also investigated if T-cell inhibition using rapamycin would protect against bone loss in rats. METHODS: Portasystemic shunting was performed in male Sprague...

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Detalhes bibliográficos
Main Authors: van der Merwe, Schalk W, Conradie, Maria M, Bond, Robert, Olivier, Brenda J, Fritz, Elongo, Nieuwoudt, Martin, Delport, Rhena, Slavik, Tomas, Engelbrecht, Gert, Kahn, Del, Shephard, Enid G, Kotze, Maritha J, de Villiers, Nico P, Hough, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Co., Limited 2006
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125637/
https://ncbi.nlm.nih.gov/pubmed/16874862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v12.i28.4504
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