Gene–gene interactions in breast cancer susceptibility

There have been few definitive examples of gene–gene interactions in humans. Through mutational analyses in 7325 individuals, we report four interactions (defined as departures from a multiplicative model) between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2...

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Bibliographic Details
Main Authors: Turnbull, Clare, Seal, Sheila, Renwick, Anthony, Warren-Perry, Margaret, Hughes, Deborah, Elliott, Anna, Pernet, David, Peock, Susan, Adlard, Julian W., Barwell, Julian, Berg, Jonathan, Brady, Angela F., Brewer, Carole, Brice, Glen, Chapman, Cyril, Cook, Jackie, Davidson, Rosemarie, Donaldson, Alan, Douglas, Fiona, Greenhalgh, Lynn, Henderson, Alex, Izatt, Louise, Kumar, Ajith, Lalloo, Fiona, Miedzybrodzka, Zosia, Morrison, Patrick J, Paterson, Joan, Porteous, Mary, Rogers, Mark T., Shanley, Susan, Walker, Lisa, Ahmed, Munaza, Eccles, Diana, Evans, D. Gareth, Donnelly, Peter, Easton, Douglas F., Stratton, Michael R., Rahman, Nazneen
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Association Studies Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125627/
https://ncbi.nlm.nih.gov/pubmed/22072393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr525
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