Epigenetic modification of the FoxP3 TSDR in HAM/TSP decreases the functional suppression of Tregs

HTLV-1 is a human retrovirus that is associated with the neuroinflammatory disorder HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP). In these patients, HTLV-1 is primarily found in the CD4(+)CD25(+) T cell subset (Regulatory T cells:Tregs), which is responsible for peripheral im...

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Autori principali: Anderson, Monique R, Enose-Akahata, Yoshimi, Massoud, Raya, Ngouth, Nyater, Tanaka, Yuetsu, Oh, Unsong, Jacobson, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125438/
https://ncbi.nlm.nih.gov/pubmed/24845974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-014-9547-z
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