Eliciting Neutralizing Antibodies with gp120 Outer Domain Constructs Based on M-Group Consensus Sequence

One strategy being evaluated for HIV-1 vaccine development is focusing immune responses towards neutralizing epitopes on the gp120 outer domain (OD) by removing the immunodominant, but non-neutralizing, inner domain. Previous OD constructs have not elicited strong neutralizing antibodies (nAbs). We...

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Detalhes bibliográficos
Main Authors: Qin, Yali, Banasik, Marisa, Kim, SoonJeung, Penn-Nicholson, Adam, Habte, Habtom H, Labranche, Celia, Montefiori, David C, Wang, Chong, Cho, Michael W
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125429/
https://ncbi.nlm.nih.gov/pubmed/25046154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.06.006
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