Testing Models of the APC Tumor Suppressor/β-Catenin Interaction Reshapes Our View of the Destruction Complex in Wnt Signaling

The Wnt pathway is a conserved signal transduction pathway that contributes to normal development and adult homeostasis, but is also misregulated in human diseases such as cancer. The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator of Wnt signaling inactivated in...

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Dades bibliogràfiques
Autors principals: Yamulla, Robert J., Kane, Eric G., Moody, Alexandra E., Politi, Kristin A., Lock, Nicole E., Foley, Andrew V. A., Roberts, David M.
Format: Artigo
Idioma:Inglês
Publicat: Genetics Society of America 2014
Matèries:
Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125400/
https://ncbi.nlm.nih.gov/pubmed/24931405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.166496
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