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The Principal Role of Ku in Telomere Length Maintenance Is Promotion of Est1 Association with Telomeres
Telomere length is tightly regulated in cells that express telomerase. The Saccharomyces cerevisiae Ku heterodimer, a DNA end-binding complex, positively regulates telomere length in a telomerase-dependent manner. Ku associates with the telomerase RNA subunit TLC1, and this association is required f...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Genetics Society of America
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4125388/ https://ncbi.nlm.nih.gov/pubmed/24879463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.164707 |
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