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CBFβ and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish
CBFβ and RUNX1 form a DNA-binding heterodimer and are both required for hematopoietic stem cell (HSC) generation in mice. However, the exact role of CBFβ in the production of HSCs remains unclear. Here, we generated and characterized 2 zebrafish cbfb null mutants. The cbfb(−/−) embryos underwent pri...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4125354/ https://ncbi.nlm.nih.gov/pubmed/24850758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-531988 |
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