Comprehensive Identification of Single Nucleotide Polymorphisms Associated with Beta-lactam Resistance within Pneumococcal Mosaic Genes

Traditional genetic association studies are very difficult in bacteria, as the generally limited recombination leads to large linked haplotype blocks, confounding the identification of causative variants. Beta-lactam antibiotic resistance in Streptococcus pneumoniae arises readily as the bacteria ca...

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Autores principales: Chewapreecha, Claire, Marttinen, Pekka, Croucher, Nicholas J., Salter, Susannah J., Harris, Simon R., Mather, Alison E., Hanage, William P., Goldblatt, David, Nosten, Francois H., Turner, Claudia, Turner, Paul, Bentley, Stephen D., Parkhill, Julian
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125147/
https://ncbi.nlm.nih.gov/pubmed/25101644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004547
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