Random Migration and Signal Integration Promote Rapid and Robust T Cell Recruitment

To fight infections, rare T cells must quickly home to appropriate lymph nodes (LNs), and reliably localize the antigen (Ag) within them. The first challenge calls for rapid trafficking between LNs, whereas the second may require extensive search within each LN. Here we combine simulations and exper...

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Autores principales: Textor, Johannes, Henrickson, Sarah E., Mandl, Judith N., von Andrian, Ulrich H., Westermann, Jürgen, de Boer, Rob J., Beltman, Joost B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125054/
https://ncbi.nlm.nih.gov/pubmed/25102014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003752
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