Random Migration and Signal Integration Promote Rapid and Robust T Cell Recruitment

To fight infections, rare T cells must quickly home to appropriate lymph nodes (LNs), and reliably localize the antigen (Ag) within them. The first challenge calls for rapid trafficking between LNs, whereas the second may require extensive search within each LN. Here we combine simulations and exper...

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Hlavní autoři: Textor, Johannes, Henrickson, Sarah E., Mandl, Judith N., von Andrian, Ulrich H., Westermann, Jürgen, de Boer, Rob J., Beltman, Joost B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125054/
https://ncbi.nlm.nih.gov/pubmed/25102014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003752
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