KDM6 Demethylase Independent Loss of Histone H3 Lysine 27 Trimethylation during Early Embryonic Development

The early mammalian embryo utilizes histone H3 lysine 27 trimethylation (H3K27me3) to maintain essential developmental genes in a repressive chromatin state. As differentiation progresses, H3K27me3 is removed in a distinct fashion to activate lineage specific patterns of developmental gene expressio...

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Bibliographic Details
Main Authors: Shpargel, Karl B., Starmer, Joshua, Yee, Della, Pohlers, Michael, Magnuson, Terry
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125042/
https://ncbi.nlm.nih.gov/pubmed/25101834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004507
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