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Large Scale Characterization of the LC13 TCR and HLA-B8 Structural Landscape in Reaction to 172 Altered Peptide Ligands: A Molecular Dynamics Simulation Study

The interplay between T cell receptors (TCRs) and peptides bound by major histocompatibility complexes (MHCs) is one of the most important interactions in the adaptive immune system. Several previous studies have computationally investigated their structural dynamics. On the basis of these simulatio...

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Autors principals: Knapp, Bernhard, Dunbar, James, Deane, Charlotte M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125040/
https://ncbi.nlm.nih.gov/pubmed/25101830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003748
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