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Large Scale Characterization of the LC13 TCR and HLA-B8 Structural Landscape in Reaction to 172 Altered Peptide Ligands: A Molecular Dynamics Simulation Study

The interplay between T cell receptors (TCRs) and peptides bound by major histocompatibility complexes (MHCs) is one of the most important interactions in the adaptive immune system. Several previous studies have computationally investigated their structural dynamics. On the basis of these simulatio...

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Detalhes bibliográficos
Main Authors: Knapp, Bernhard, Dunbar, James, Deane, Charlotte M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125040/
https://ncbi.nlm.nih.gov/pubmed/25101830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003748
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