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Targeting DNA repair pathways for cancer treatment: what's new?

Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A growing body of evidence indicates that tumors accumulate progressively more mutations in DNA repair proteins as cancers progress. DNA repair mechanisms greatly affect the response to cytotoxic treatments, so understan...

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Bibliografische gegevens
Hoofdauteurs: Kelley, Mark R, Logsdon, Derek, Fishel, Melissa L
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125008/
https://ncbi.nlm.nih.gov/pubmed/24947262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fon.14.60
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