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Targeting DNA repair pathways for cancer treatment: what's new?

Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A growing body of evidence indicates that tumors accumulate progressively more mutations in DNA repair proteins as cancers progress. DNA repair mechanisms greatly affect the response to cytotoxic treatments, so understan...

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Detalhes bibliográficos
Main Authors: Kelley, Mark R, Logsdon, Derek, Fishel, Melissa L
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125008/
https://ncbi.nlm.nih.gov/pubmed/24947262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fon.14.60
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