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A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication
Cell cycle arrest in response to hypoxia is a fundamental physiological mechanism to maintain a balance between O(2) supply and demand. Many of the cellular responses to reduced O(2) availability are mediated through the transcriptional activity of hypoxia-inducible factor 1 (HIF-1). We report a rol...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4124626/ https://ncbi.nlm.nih.gov/pubmed/23405012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003417 |
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