A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication

Cell cycle arrest in response to hypoxia is a fundamental physiological mechanism to maintain a balance between O(2) supply and demand. Many of the cellular responses to reduced O(2) availability are mediated through the transcriptional activity of hypoxia-inducible factor 1 (HIF-1). We report a rol...

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Main Authors: Hubbi, Maimon E., Kshitiz, Gilkes, Daniele M., Rey, Sergio, Wong, Carmen C., Luo, Weibo, Kim, Deok-Ho, Dang, Chi V., Levchenko, Andre, Semenza, Gregg L.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124626/
https://ncbi.nlm.nih.gov/pubmed/23405012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003417
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