The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.
The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). The cloning and specific alteration of the biosynthetic genes for these polyketides might allow the biosynthesi...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41241/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7644502/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.17.7839 |
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