The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.

The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). The cloning and specific alteration of the biosynthetic genes for these polyketides might allow the biosynthesi...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Schwecke, T, Aparicio, J F, Molnár, I, König, A, Khaw, L E, Haydock, S F, Oliynyk, M, Caffrey, P, Cortés, J, Lester, J B
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41241/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7644502/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.17.7839
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