Inhibition of Phosphodiesterase 2 Augments cGMP and cAMP Signaling to Ameliorate Pulmonary Hypertension

BACKGROUND: Pulmonary hypertension (PH) is a life-threatening disorder characterized by increased pulmonary artery pressure, remodeling of the pulmonary vasculature, and right ventricular failure. Loss of endothelium-derived nitric oxide (NO) and prostacyclin (PGI(2)) contributes to PH pathogenesis...

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Huvudupphovsmän: Bubb, Kristen J, Trinder, Sarah L, Baliga, Reshma S, Patel, Jigisha, Clapp, Lucie H, MacAllister, Raymond J, Hobbs, Adrian J
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124037/
https://ncbi.nlm.nih.gov/pubmed/24899690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.114.009751
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