The PYRIN domain-only protein POP3 inhibits AIM2-like receptor inflammasomes and regulates responses to DNA virus infections

The innate immune system responds to infections and tissue damage by activating cytosolic sensory complexes called inflammasomes. Cytosolic DNA is sensed by AIM2-like receptors (ALRs) during bacterial and viral infections and in autoimmune diseases. Subsequently, recruitment of the adaptor protein A...

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Bibliografiske detaljer
Main Authors: Khare, Sonal, Ratsimandresy, Rojo A., de Almeida, Lúcia, Cuda, Carla M., Rellick, Stephanie L., Misharin, Alexander V., Wallin, Melissa C., Gangopadhyay, Anu, Forte, Eleonora, Gottwein, Eva, Perlman, Harris, Reed, John C., Greaves, David R., Dorfleutner, Andrea, Stehlik, Christian
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123781/
https://ncbi.nlm.nih.gov/pubmed/24531343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2829
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