Speckle-type POZ protein, SPOP, is involved in the DNA damage response

Speckle-type POZ protein (SPOP) is an adaptor of the cullin 3-based ubiquitin ligase responsible for the degradation of oncoproteins frequently overexpressed in many tumor cells. Altered expression and somatic mutations of SPOP have been observed in various tumor types with chromosomal aberrations,...

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Autori principali: Zhang, Dan, Wang, Haibo, Sun, Mianen, Yang, Jun, Zhang, Wei, Han, Suxia, Xu, Bo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123640/
https://ncbi.nlm.nih.gov/pubmed/24451148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu022
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