Synthesis of FVIII in Hemophilia-A patients with the intron-22-inversion may modulate immunogenicity

Neutralizing antibodies (inhibitors) to replacement Factor-VIII impair the effective management of hemophilia-A(1). Individuals with hemophilia-A due to major F8 gene disruptions lack antigenically cross-reactive material in their plasma (CRM-negative) and prevalence of inhibitors is >60%. Conver...

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Main Authors: Pandey, Gouri Shankar, Yanover, Chen, Miller-Jenkins, Lisa M., Garfield, Susan, Cole, Shelley A., Curran, Joanne E., Moses, Eric K., Rydz, Natalia, Simhadri, Vijaya, Kimchi-Sarfaty, Chava, Lillicrap, David, Viel, Kevin, Przytycka, Teresa M., Pierce, Glenn F., Howard, Tom E., Sauna, Zuben E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123441/
https://ncbi.nlm.nih.gov/pubmed/24037092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3270
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