DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease

Parkinson's disease (PD) is a devastating neurodegenerative disorder characterized by the loss of neurons in the substantia nigra pars compacta and the presence of Lewy bodies in surviving neurons. These intracellular protein inclusions are primarily composed of misfolded α-synuclein (aSyn), wh...

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Bibliographic Details
Main Authors: Zondler, L, Miller-Fleming, L, Repici, M, Gonçalves, S, Tenreiro, S, Rosado-Ramos, R, Betzer, C, Straatman, K R, Jensen, P H, Giorgini, F, Outeiro, T F
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123098/
https://ncbi.nlm.nih.gov/pubmed/25058424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.307
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