DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease

Parkinson's disease (PD) is a devastating neurodegenerative disorder characterized by the loss of neurons in the substantia nigra pars compacta and the presence of Lewy bodies in surviving neurons. These intracellular protein inclusions are primarily composed of misfolded α-synuclein (aSyn), wh...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zondler, L, Miller-Fleming, L, Repici, M, Gonçalves, S, Tenreiro, S, Rosado-Ramos, R, Betzer, C, Straatman, K R, Jensen, P H, Giorgini, F, Outeiro, T F
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2014
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123098/
https://ncbi.nlm.nih.gov/pubmed/25058424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.307
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