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Examination of FMR1 transcript and protein levels among 74 premutation carriers

Fragile X-associated disorders are caused by a CGG trinucleotide repeat expansion in the 5′-untranslated region of the FMR1 gene. Expansion of the CGG trinucleotide repeats to >200 copies (that is, a full mutation) induces methylation of the FMR1 gene, with transcriptional silencing being the eve...

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Detalhes bibliográficos
Main Authors: Peprah, Emmanuel, He, Weiya, Allen, Emily, Oliver, Tiffany, Boyne, Alex, Sherman, Stephanie L
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122982/
https://ncbi.nlm.nih.gov/pubmed/19927162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jhg.2009.121
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