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Synthesis of 5-Fluoroalkylated Pyrimidine Nucleosides via Negishi Cross-Coupling
5-fluoroalkylated pyrimidine nucleosides (1) have potential as therapeutic agents and molecular imaging agents targeting HSV1-tk suicide gene therapy. Thus, straightforward preparation of 5-fluoroalkylated nucleoside derivatives has been developed. Reported herein are the first examples of Pd-cataly...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4122541/ https://ncbi.nlm.nih.gov/pubmed/18522415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo800444y |
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