Clinical and Biochemical Function of Polymorphic NR0B1 GGAA-Microsatellites in Ewing Sarcoma: A Report from the Children's Oncology Group

BACKGROUND: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood. EWS/FLI and related EWS/ETS chimeras upregulate numerous gene targets via promoter-based GGAA-microsatellite response elements. These microsatellites are highly polymorphic in humans, and prelimina...

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Hauptverfasser: Monument, Michael J., Johnson, Kirsten M., McIlvaine, Elizabeth, Abegglen, Lisa, Watkins, W. Scott, Jorde, Lynn B., Womer, Richard B., Beeler, Natalie, Monovich, Laura, Lawlor, Elizabeth R., Bridge, Julia A., Schiffman, Joshua D., Krailo, Mark D., Randall, R. Lor, Lessnick, Stephen L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122435/
https://ncbi.nlm.nih.gov/pubmed/25093581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104378
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