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Screening for Noise in Gene Expression Identifies Drug Synergies
Stochastic fluctuations are inherent to gene expression and can drive cell-fate specification. We used such fluctuations to modulate reactivation of HIV from latency—a quiescent state that is a major barrier to an HIV cure. By screening a diverse library of bioactive small molecules, we identified o...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4122234/ https://ncbi.nlm.nih.gov/pubmed/24903562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1250220 |
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