Formulation and Optimization of Polymeric Nanoparticles for Intranasal Delivery of Lorazepam Using Box-Behnken Design: In Vitro and In Vivo Evaluation

The aim of the present study was to optimize lorazepam loaded PLGA nanoparticles (Lzp-PLGA-NPs) by investigating the effect of process variables on the response using Box-Behnken design. Effect of four independent factors, that is, polymer, surfactant, drug, and aqueous/organic ratio, was studied on...

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Hauptverfasser: Sharma, Deepak, Maheshwari, Dipika, Philip, Gilphy, Rana, Ravish, Bhatia, Shanu, Singh, Manisha, Gabrani, Reema, Sharma, Sanjeev K., Ali, Javed, Sharma, Rakesh Kumar, Dang, Shweta
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122152/
https://ncbi.nlm.nih.gov/pubmed/25126544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/156010
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