Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles

The objective of the present investigation was to optimize diazepam (Dzp)-loaded poly(lactic-co-glycolic acid) nanoparticles (NP) to achieve delivery in the brain through intranasal administration. Dzp nanoparticles (DNP) were formulated by nanoprecipitation and optimized using Box-Behnken design. T...

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Bibliographic Details
Published in:AAPS PharmSciTech
Main Authors: Sharma, Deepak, Sharma, Rakesh Kumar, Sharma, Navneet, Gabrani, Reema, Sharma, Sanjeev K., Ali, Javed, Dang, Shweta
Format: Artigo
Language:Inglês
Published: Springer US 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674633/
https://ncbi.nlm.nih.gov/pubmed/25698083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-015-0294-0
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