Tamoxifen Toxicity in Cultured Retinal Pigment Epithelial Cells Is Mediated by Concurrent Regulated Cell Death Mechanisms

PURPOSE. To evaluate the mechanism of tamoxifen-induced cell death in human cultured RPE cells, and to investigate concurrent cell death mechanisms including pyroptosis, apoptosis, and necroptosis. METHODS. Human RPE cells were cultured until confluence and treated with tamoxifen; cell death was mea...

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Главные авторы: Kim, Leo A., Amarnani, Dhanesh, Gnanaguru, Gopalan, Tseng, Wen Allen, Vavvas, Demetrios G., D'Amore, Patricia A.
Формат: Artigo
Язык:Inglês
Опубликовано: The Association for Research in Vision and Ophthalmology 2014
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122018/
https://ncbi.nlm.nih.gov/pubmed/24994868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-13662
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