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Tamoxifen Toxicity in Cultured Retinal Pigment Epithelial Cells Is Mediated by Concurrent Regulated Cell Death Mechanisms

PURPOSE. To evaluate the mechanism of tamoxifen-induced cell death in human cultured RPE cells, and to investigate concurrent cell death mechanisms including pyroptosis, apoptosis, and necroptosis. METHODS. Human RPE cells were cultured until confluence and treated with tamoxifen; cell death was mea...

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Detalhes bibliográficos
Main Authors: Kim, Leo A., Amarnani, Dhanesh, Gnanaguru, Gopalan, Tseng, Wen Allen, Vavvas, Demetrios G., D'Amore, Patricia A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122018/
https://ncbi.nlm.nih.gov/pubmed/24994868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-13662
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